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Long-term planning matters

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Semaglutide's ability to depress appetite, advance glucose control, and promote sustained weight loss makes it appealing

While estimands do not solve all problems of trial design and interpretation, this new concept will enable trials to be designed more appropriately to obtain relevant information to address the clinical question(s) of interest

Tirzepatide is a novel glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for the treatment of type 2 diabetes mellitus (Mounjaro) and chronic weight management (Zepbound)

Recommended maintenance doses are: 5mg, 10mg, or 15mg